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Fig. 2

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ZDB-FIG-250829-2

Publication

Ayala et al., 2025 - Azole drugs have differential efficacy in varied models of immunosuppression in larval zebrafish hosts

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Fig. 2

Azoles have differing efficacy and toxicity in dexamethasone-immunosuppressed larvae. 2 dpf wild-type larvae were injected with A. fumigatus spores (TBK1.1), 10 µM dexamethasone or vehicle control and antifungal drugs or vehicle control were added to the larval water, and survival was tracked. Data represent three pooled replicates. P values and hazard ratios were calculated by Cox proportional hazard analysis. A. Larvae were treated with vehicle control, 2.5 µg/ml posaconazole, 1 µg/ml itraconazole, 0.5 µg/ml isavuconazole, or 1 µg/ml voriconazole. Average injection CFUs = 39. B. Larvae were treated with vehicle control or 1 µg/ml itraconazole. Average injection CFUs = 70.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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