FIGURE

Fig. 1

ID

ZDB-FIG-250829-1

Publication

Ayala et al., 2025 - Azole drugs have differential efficacy in varied models of immunosuppression in larval zebrafish hosts

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Fig. 1

Voriconazole is effective in chemically-immunosuppressed larvae. 2 dpf larvae were injected with A. fumigatus spores, immunosuppressive drugs and/or antifungal drugs and/or vehicle control were added to the larval water, and survival was tracked. Data represent at least three pooled replicates. P values and hazard ratios were calculated by Cox proportional hazard analysis. A. Experimental setup. B. Wild-type larvae infected with TBK1.1 were treated with 10 µM indomethacin or vehicle control and/or 1 µg/ml voriconazole or vehicle control. Average injection CFUs = 25. C. Wild-type larvae infected with TBK5.1 were treated with 10 µM dexamethasone or vehicle control and/or 1 µg/ml voriconazole or vehicle control. Average injection CFUs = 45. D. Neutrophil-defective mpx:rac2D57N larvae infected with TBK1.1 were treated with vehicle control (top), 10 µM indomethacin (bottom left), or 10 µM dexamethasone (bottom right) and 1 µg/ml voriconazole or vehicle control. Average injection CFUs = 43.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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