FIGURE

Fig. 7

ID

ZDB-FIG-250717-44

Publication

Azhwar et al., 2025 - Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Cross-species rescue of fibrin deposition in f8–/–;at3–/– larvae by FVIII and VWF. (A) Model demonstrating the effect of FVIII levels on fibrin deposition. (B) f8–/–;at3–/– zebrafish larvae were injected with various combinations of plasmids encoding human (h) and zebrafish (z) FVIII and VWF and analyzed for fibrin deposition at 5 dpf by an observer blinded to condition. Injection groups included: uninjected controls, hVWF, hF8, zvwf, zf8, coinjection of hVWF + hF8, coinjection of zvwf + zf8, and cross-species combinations (hVWF + zf8 and zvwf + hF8). (C) Comparison of various groups shows that hVWF, but not zvwf, enhances fibrin deposition in combination with human or fish FVIII. Statistical analysis was performed using ordinal logistic regression followed by Dunnett's adjustments. (∗P < .05, ∗∗P < .01, ∗∗∗P < .001). ns, nonsignificant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Blood Adv