FIGURE

Fig. 3

ID

ZDB-FIG-250717-36

Publication

Chen et al., 2025 - The novel role of foxi3 in zebrafish mandibular development

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Fig. 3

Disruption of foxi3a or foxi3b decreases cranial neural crest cell number and leads to the hypoplastic mandibular cartilage in zebrafish. A. Maximum projections of confocal live imaging Z stacks acquired from foxi3a and foxi3b Tg(sox10:GFP) and Tg(col2a1a:mCherry) zebrafish. Lateral views of foxi3a and foxi3b Tg(sox10:GFP) crispants show a significant reduction in CNCCs compared with controls at 24 and 48 hpf. Dorsal views of foxi3a and foxi3b Tg(sox10:GFP) and Tg(col2a1a:mCherry) crispants show hypoplastic mandibular cartilage at 72 and 120 hours postfertilization (hpf). Scale bars, 200 μm. B. Quantification of CNCCs at 24 and 48 hpf (n = 10 larvae per group for each time point; unpaired t-test). C. Quantification of the length of Meckel's cartilage (m) and palatoquadrate (pq) at 120 hpf (n = 8 larvae per group for each time point). All error bars indicate mean ± standard deviation. *p < 0.05, **p < 0.01, and ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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