Figure 1

Developmental toxicity assessment of lurasidone exposure on zebrafish embryos. (A) Schematic illustration of the experimental design and morphological parameters measured in this study. (B) Schematic representation of zones and (C) heatmap visualization of touch-response patterns. (D, E) Temporal dynamics of survival and hatching rates from 1 to 5 days post-fertilization (dpf). (F-H) Morphometric analysis at 5 dpf showing body length, pericardial area, and yolk sac area measurements across groups. (I) Zone-specific residence time distribution and (J) representative locomotor trajectories following lurasidone exposure. (K-M) Quantitative behavioral parameters including total distance traveled, average swimming speed, and cumulative active movement duration. Data are presented as mean ± SE; statistical significance: *P < 0.05, **P < 0.01, ***P < 0.001 compared to control group; ns: not significant. No hatching was observed at 24 hours post-fertilization (hpf).