FIGURE

Fig. 4

ID

ZDB-FIG-250708-50

Publication

Monfries et al., 2025 - frizzled5 mutant zebrafish are genetically sensitised to developing microphthalmia and coloboma

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Fig. 4

fzd5sgu1 and fzd5sgu3 are genetically sensitised to developing eye malformations. (A,B,D-F,H,I) Lateral views, with anterior to the left, of 72 hpf embryos treated with DMSO (A,D,H) or XAV-939 (B,E,F,I). Colobomas (arrows in B,F,I) are evident in a subset of embryos derived from the incross of fzd5sgu1/+ (B), MZfzd5sgu1 (F) and fzd5sgu3/+ XAV-939-treated embryos (I), a phenotype never observed in wild-type XAV-939-treated embryos (E). (C,G,J) Quantification of phenotypes observed, and their associated genotypes, in XAV-939-treated embryos derived from fzd5sgu1/+ incross (C), wild-type or MZfzd5sgu1 incross (G) and fzd5sgu3/+ incross (J). Scale bar: 500 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT fzd5^sgu1/sgu1 fzd5^sgu1/sgu1 fzd5^sgu3/sgu3 fzd5^sgu3/+
Condition:	chemical treatment by environment: XAV939
Observed In:	optic furrow
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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