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Fig. 4

ID: ZDB-IMAGE-250708-50
Publication: Monfries et al., 2025 - frizzled5 mutant zebrafish are genetically sensitised to developing microphthalmia and coloboma
All Figures: Figures for Monfries et al., 2025

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Fig. 4 fzd5sgu1 and fzd5sgu3 are genetically sensitised to developing eye malformations. (A,B,D-F,H,I) Lateral views, with anterior to the left, of 72 hpf embryos treated with DMSO (A,D,H) or XAV-939 (B,E,F,I). Colobomas (arrows in B,F,I) are evident in a subset of embryos derived from the incross of fzd5sgu1/+ (B), MZfzd5sgu1 (F) and fzd5sgu3/+ XAV-939-treated embryos (I), a phenotype never observed in wild-type XAV-939-treated embryos (E). (C,G,J) Quantification of phenotypes observed, and their associated genotypes, in XAV-939-treated embryos derived from fzd5sgu1/+ incross (C), wild-type or MZfzd5sgu1 incross (G) and fzd5sgu3/+ incross (J). Scale bar: 500 µm.

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