FIGURE

Fig. 5

ID

ZDB-FIG-250708-51

Publication

Monfries et al., 2025 - frizzled5 mutant zebrafish are genetically sensitised to developing microphthalmia and coloboma

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Fig. 5

Overexpression of a dominant-negative form of Fzd5 in the optic primordium results in eye defects. (A-C) 14 hpf embryos stained with the pan retinal marker mab21l2 showing incomplete optic vesicle evagination in tg(rx3:Gal4);UAS:fzd5DN [asterisks in B,C, compare with wild-type expression pattern in tg(rx3:Gal4) controls in A]. (D-F) pax2.1 expression at 72 hpf highlighting optic nerve defects and optic disc coloboma in tg(rx3:Gal4);UAS:fzd5DN (E, asterisk; F, arrows) compared to tg(rx3:Gal4) controls (D). Panels show dorsal (A-C) or ventral (G-I) views of embryo heads with anterior to the left. Scale bars: 100 µm.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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