FIGURE

Fig 7

ID

ZDB-FIG-250705-16

Publication

Rissone et al., 2025 - The transcription factors Tfeb and Tfe3 are required for survival and embryonic development of pancreas and liver in zebrafish

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Fig 7

TKO embryos show higher sensitivity to different kinds of cellular stress.

(A-D) Kaplan-Meier curves comparing the survival rates of WT and TKO embryos at increasing doses of NaAsO₂ (untreated (A), 1mM (B), 1.5 mM (C), 2 mM (D)). At each dosage, WT embryos were used as controls. The number of embryos per group is indicated in parenthesis. (E-I) Kaplan-Meier curves showing the survival rates of WT and TKO embryos following continuous exposure to heat shock treatments until 3 dpf. The red dashed lines highlight the beginning of each heat-shock (HS) treatment. Untreated embryos (E) were used as a control for the quality of the batch of embryos used for the treatments. In each treatment, WT embryos were used as internal controls. The number in parenthesis indicate the embryos used in each treatment. Logrank tests: **** < 0.0001. Data show one representative experiment out of three independently performed.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tfe3a^hg153/hg153; tfeb^hg151/hg151; tfeb^hg152/hg152; tfe3b^hg154/hg154
Conditions:	chemical treatment by environment: sodium arsenite heat shock
Observed In:	cellular response to temperature stimulus response to sodium arsenite whole organism whole organism sodium arsenite
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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