FIGURE

Fig. 9

ID

ZDB-FIG-250627-111

Publication

Siegerist et al., 2025 - The differential expression of MAGI2 in glomerulopathies and its application as a molecular discriminator of podocytopathies

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Fig. 9

Evaluation of proteinuria in nphs1 and magi2a KO embryos. A shows the general morphology of larvae which were either uninjected, injected with control RNPs, or with nphs1 or magi2a RNPs. The fluorescence microcraphs in B show the filtered and reabsorbed gc-eGFP fusion protein in proximal tubules, but not in control- or uninjected embryos. As shown in C, in the beforehand established high-content proteinuria screening approach, nphs1 KO embryos were proteinuric at day 4 and 5 as demonstrated by decreased intravascular gc-eGFP fluorescence, while magi2a KO embryos were significantly proteinuric later at day 5. Scale bars indicate 200 µm in the overview and 100 µm in the zoom inserts

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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