FIGURE

Fig. 2

ID

ZDB-FIG-250507-2

Publication

Liu et al., 2025 - Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice

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Fig. 2

The loss of STX12 elicites an inflammatory response predominantly in lung tissue. A Representative images of TMRM staining (50 nM) of MEFs from Stx12−/− mice and littermate controls. B Quantification of the relative TMRM fluorescence intensity normalized to WT. The results are presented as the mean ± SEM; statistical significance was assessed by Student’s t- test. C, D The cytokine kit displays of serum from Stx12−/− mice (HO) and the littermate controls (WT, Stx12+/+) (R&D Systems, Catalog # 410-MT) and quantitative analysis. E, F The cytokine kit displays of lung lysates from Stx12−/− mice (HO) and the littermate controls (WT, Stx12+/+) (R&D Systems, Catalog # 410-MT) and quantitative analysis. G, H The cytokine kit displays of brain lysates from Stx12−/− mice (HO) and the littermate controls (WT, Stx12+/+) (R&D Systems, Catalog # 410-MT) and quantitative analysis. The Stx12−/− mice and their littermate controls were obtained at embryonic day 19.5 (E19.5)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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