FIGURE

Fig. 2

ID

ZDB-FIG-250501-29

Publication

Shin et al., 2025 - Seizure-like behavior and hyperactivity in napb knockout zebrafish as a model for autism and epilepsy

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Fig. 2

Electrical hyperexcitability in napb CR. Neural activity and neural network were monitored using MEA. (A) Inverted microscope image of a control zebrafish larva, laterally immobilized on the electrodes of MEA plates. (B) Heat map of spontaneous spike amplitude (µV) of a control zebrafish, showing that detected extracellular activity aligns with the zebrafish’s orientation (white dot). The red circle indicates the head region. (C) Well-wide raster plot illustrating synchronized spinal cord and brain neural activity in the control zebrafish. The red dotted line indicates neural activity in the brain region. (D-F) Hyperactive neural activity of napb CR. (D, E) Heat map of spontaneous spike amplitude (µV) and (F) raster plot of napb CR. (G) The number of zebrafish larvae exhibiting hyperactive neural activity in the brain region; control (n = 21) and napb CR (n = 21).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + CRISPR1-napba + CRISPR1-napbb + CRISPR2-napba + CRISPR2-napbb
Condition:	chemical treatment by environment: pentetrazol
Knockdown Reagents:	CRISPR1-napba CRISPR1-napbb CRISPR2-napba CRISPR2-napbb
Observed In:	brain action potential
Stage:	Day 5

Phenotype Detail

Acknowledgments

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