FIGURE

Fig. 6

ID

ZDB-FIG-250430-164

Publication

Garcia-Peiro et al., 2025 - Dendritic Platinum Nanoparticles Shielded by Pt-S PEGylation as Intracellular Reactors for Bioorthogonal Uncaging Chemistry

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Fig. 6

a) Schematic timeline of the Pt(0)-mediated prodrug activation in vivo assay (created with BioRender). dpf: days post-fertilization; hpi: hours post-injection. b) Confocal microscopy images of nuclei-labeled HCT116 cells (cyan) implanted in the PVS of 2-dpf zebrafish larvae after 2 days of incubation in E3 medium with or without pro-SN38. Groups: non-Pt-treated cells+pro-SN38 (left); PEG-dPt-2-treated cells+DMSO (middle), and PEG-dPt-2-treated cells+pro-SN38 (left). N=9–12. The dashed line represents the tumor area. Scale bars=50 μm. BgF: Background fluorescence. c, Measurement of tumor size between groups after treatment. d) Analysis of the number of nuclei-labeled cancer cells between groups after treatment. e) Quantitative analysis of green fluorescence signal (Ex=514 nm). Statistical analysis: one-way ANOVA followed by Tukey's post-hoc test: ns>0.05, * P≤0.05, ** P≤0.01, *** P≤0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Angew. Chem. Int. Ed. Engl.