FIGURE

FIGURE 3

ID

ZDB-FIG-250419-5

Publication

Sun et al., 2025 - Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish

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FIGURE 3

popdc3 deficiency promotes zebrafish skeletal muscle protein degradation and inhibits protein synthesis. (a) qRT‐PCR to detect the gene expression of trim63a, trim63b, fbxo32, atg9a, atg9b, atg101, rb1cc1, ulk2 and lc3a. (b) Western blotting was used to detect the protein expression of Murf and Fbxo2 and autophagy‐related proteins (Beclin1 and P62) expression. (c) qRT‐PCR to detect the gene expression of igf1, pik3r2, pik3r4, akt2a, akt3a and ztor. (d) Western blotting was used to detect the protein expression of p‐Pi3k and p‐Akt (n = 6). Data are shown as mean ± SD. *p < 0.05, **p < 0.01 and ***p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Cachexia Sarcopenia Muscle