Gene
ulk2
- ID
- ZDB-GENE-090218-30
- Name
- unc-51 like autophagy activating kinase 2
- Symbol
- ulk2 Nomenclature History
- Previous Names
-
- im:7164951 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within dendrite arborization; habenula development; and regulation of dendrite morphogenesis. Predicted to be active in autophagosome; cytosol; and phagophore assembly site membrane. Is expressed in habenula; hatching gland; polster; sensory system; and trigeminal placode. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7164951 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ulk2 | Ding et al., 2022 | |
| MO1-ulk2 | N/A | Taylor et al., 2011 |
| MO2-ulk2 | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR022708 | Serine/threonine-protein kinase Atg1-like, tMIT domain |
| Domain | IPR048941 | ATG1-like, MIT domain 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATG1-like, MIT domain 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase Atg1-like | Serine/threonine-protein kinase Atg1-like, tMIT domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:X1WEA3 | InterPro | 1034 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-87M19 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7164951 | Thisse et al., 2004 | |
| Encodes | EST | wz10435 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002664615 (1) | 4301 nt | ||
| Genomic | GenBank:CR848784 (1) | 176351 nt | ||
| Polypeptide | UniProtKB:X1WEA3 (1) | 1034 aa |
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
- Ding, Y., Wang, M., Bu, H., Li, J., Lin, X., Xu, X. (2022) An F0-based genetic assay in adult zebrafish for discovering modifier genes of an inherited cardiomyopathy. Disease models & mechanisms. 16(5):
- Ren, Q., Jiang, X., Zhang, S., Gao, X., Paudel, Y.N., Zhang, P., Wang, R., Liu, K., Jin, M. (2022) Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 147:112629
- Sugasawa, T., Komine, R., Manevich, L., Tamai, S., Takekoshi, K., Kanki, Y. (2022) Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle. Nutrients. 14(11)
- Ji, X., Wang, B., Paudel, Y.N., Li, Z., Zhang, S., Mou, L., Liu, K., Jin, M. (2021) Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy. Frontiers in molecular biosciences. 8:655549
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Li, X., Dang, J., Li, Y., Wang, L., Li, N., Liu, K., Jin, M. (2020) Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method. The Science of the total environment. 752:141878
- Zhang, S., Yu, Z., Xia, J., Zhang, X., Liu, K., Sik, A., Jin, M. (2020) Anti-Parkinson's disease activity of phenolic acids from Eucommia ulmoides Oliver leaf extracts and their autophagy activation mechanism. Food & function. 11(2):1425-1440
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Yang, B.Y., Zhai, G., Gong, Y.L., Su, J.Z., Peng, X.Y., Shang, G.H., Han, D., Jin, J.Y., Liu, H.K., Du, Z.Y., Yin, Z., Xie, S.Q. (2017) Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American journal of physiology. Endocrinology and metabolism. 315(1):E38-E51
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