FIGURE

Fig. 7

ID

ZDB-FIG-250410-20

Publication

Liu et al., 2025 - Knockout of the fcsk gene in zebrafish causes neurodevelopmental defects

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

RNA-seq analysis of WT and fcsk−/− zebrafish A: Volcano plot of differentially expressed genes (DEGs) between WT and fcsk−/− zebrafish. Blue represents down-regulated genes (750), red represents up-regulated genes (580), gray represents genes with no significant difference. B: Clustering heatmap of glycosylation-related DEGs. C: mRNA levels of glycosylation-related DEGs detected by RT-qPCR (n=3). D: Clustering heatmap of apoptosis-related DEGs. E: mRNA levels of apoptosis-related DEGs detected by RT-qPCR (n=3). F: KEGG analysis of DEGs related to the nervous system. G: Clustering heatmap of DEGs homologous to human neurodegenerative disease-related genes. H: mRNA levels of neurodegeneration-related DEGs detected by RT-qPCR (n=3). Mean±SEM. *: P<0.05; **: P<0.01; ***: P<0.001.

Expression Data

Genes:	akt2l capn2l fus gadd45ga pik3r3b pmaip1 st8sia6 st8sia7.1 zgc:162184
Fish:	AB fcsk^{hzu301/hzu301} (AB)
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fcsk^{hzu301/hzu301} (AB)
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Zool Res