Gene
pik3r3b
- ID
- ZDB-GENE-040426-743
- Name
- phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
- Symbol
- pik3r3b Nomenclature History
- Previous Names
-
- pik3r3
- zgc:55564
- zgc:85710
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of or within phosphorylation and signal transduction. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in several structures, including immature eye; nervous system; neural tube; periderm; and skeletal muscle. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55564 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR032498 | PI3K regulatory subunit p85-related , inter-SH2 domain |
| Domain | IPR035020 | PI3K p85 subunit, C-terminal SH2 domain |
| Domain | IPR035022 | PI3K p85 subunit, N-terminal SH2 domain |
| Family | IPR051854 | Rho-type GTPase-activating protein |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | PI3K p85 subunit, C-terminal SH2 domain | PI3K p85 subunit, N-terminal SH2 domain | PI3K regulatory subunit p85-related , inter-SH2 domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | Rho-type GTPase-activating protein | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PRX4 | InterPro | 317 | ||||||||||
| UniProtKB:Q66I41 | InterPro | 464 | ||||||||||
| UniProtKB:A0A8M9PLR5 | InterPro | 520 | ||||||||||
| UniProtKB:A0A8M2BDR6 | InterPro | 438 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3r3b-201
(1)
|
Ensembl | 7,940 nt | ||
| ncRNA |
pik3r3b-002
(1)
|
Ensembl | 863 nt |
Interactions and Pathways
No data available
Plasmids
No data available