Gene

pik3r3b

ID
ZDB-GENE-040426-743
Name
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
Symbol
pik3r3b Nomenclature History
Previous Names
  • pik3r3
  • zgc:55564
  • zgc:85710
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway; phosphatidylinositol phosphorylation; and regulation of phosphatidylinositol 3-kinase activity. Predicted to localize to phosphatidylinositol 3-kinase complex. Is expressed in immature eye; nervous system; neural tube; periderm; and somite. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pik3r3b Human Ortholog
No data available
Associated With pik3r3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR000980 SH2 domain
Domain IPR001452 SH3 domain
Domain IPR032498 PI3K regulatory subunit p85-related , inter-SH2 domain
Domain IPR035020 PI3K p85 subunit, C-terminal SH2 domain
Domain IPR035022 PI3K p85 subunit, N-terminal SH2 domain
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length PI3K p85 subunit, C-terminal SH2 domain PI3K p85 subunit, N-terminal SH2 domain PI3K regulatory subunit p85-related , inter-SH2 domain Rho GTPase-activating protein domain Rho GTPase activation protein SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily
UniProtKB:A0A8M9PRX4 317
UniProtKB:Q66I41 464
UniProtKB:A0A8M9PLR5 520
UniProtKB:A0A8M2BDR6 438
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations