Gene

pik3r3b

ID

ZDB-GENE-040426-743

Name

phosphoinositide-3-kinase, regulatory subunit 3b (gamma)

Symbol

pik3r3b Nomenclature History

Previous Names

pik3r3
zgc:55564
zgc:85710

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway; phosphatidylinositol phosphorylation; and regulation of phosphatidylinositol 3-kinase activity. Predicted to localize to phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Is expressed in immature eye; nervous system; neural tube; periderm; and somite. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:55564 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pik3r3b Human Ortholog

No data available

Associated With pik3r3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000198	Rho GTPase-activating protein domain
Domain	IPR000980	SH2 domain
Domain	IPR001452	SH3 domain
Domain	IPR032498	PI3K regulatory subunit p85-related , inter-SH2 domain
Domain	IPR035020	PI3K p85 subunit, C-terminal SH2 domain
Domain	IPR035022	PI3K p85 subunit, N-terminal SH2 domain
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	PI3K p85 subunit, C-terminal SH2 domain	PI3K p85 subunit, N-terminal SH2 domain	PI3K regulatory subunit p85-related , inter-SH2 domain	Rho GTPase-activating protein domain	Rho GTPase activation protein	SH2 domain	SH2 domain superfamily	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M9PRX4 InterPro	317
UniProtKB:Q66I41 InterPro	464
UniProtKB:A0A8M9PLR5 InterPro	520
UniProtKB:A0A8M2BDR6 InterPro	438

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pik3r3b-201 (1) Ensembl	Havana	7940 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	pik3r3b-002 (1) Ensembl	Havana	863 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations