Gene

pik3r3b

ID
ZDB-GENE-040426-743
Name
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
Symbol
pik3r3b Nomenclature History
Previous Names
  • pik3r3
  • zgc:55564
  • zgc:85710
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of or within phosphorylation and signal transduction. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in several structures, including immature eye; nervous system; neural tube; periderm; and skeletal muscle. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pik3r3b Human Ortholog
No data available
Associated With pik3r3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR000980 SH2 domain
Domain IPR001452 SH3 domain
Domain IPR032498 PI3K regulatory subunit p85-related , inter-SH2 domain
Domain IPR035020 PI3K p85 subunit, C-terminal SH2 domain
1 - 5 of 10 Show all
Domain Details Per Protein
Protein Additional Resources Length PI3K p85 subunit, C-terminal SH2 domain PI3K p85 subunit, N-terminal SH2 domain PI3K regulatory subunit p85-related , inter-SH2 domain Rho GTPase-activating protein domain Rho GTPase activation protein Rho-type GTPase-activating protein SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily
UniProtKB:A0A8M9PRX4 InterPro 317
UniProtKB:Q66I41 InterPro 464
UniProtKB:A0A8M9PLR5 InterPro 520
UniProtKB:A0A8M2BDR6 InterPro 438
1 - 4 of 4
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pik3r3b-201 (1)
Ensembl
Ensembl 7,940 nt
ZFIN BLAST
ncRNA pik3r3b-002 (1)
Ensembl
Ensembl 863 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.