FIGURE

Fig. 5

ID

ZDB-FIG-250409-35

Publication

Raterman et al., 2024 - foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Foxe1 mutants and wild types are severely affected by 1% ethanol exposure. (A) Representative images of the effects of 1% ethanol exposure on bone and cartilage development in wild type and mutant larvae at 120 hpf. At 1% ethanol concentration, most of the fish were mildly phenotypic, mostly showing defects in bone development. In 17% (6/35) of wild types and 28% (14/49) of mutants more severe phenotypes were observed. In case of a more severe phenotype, the exposed wild types retained more cartilage elements than the exposed mutants. Cb: Ceratobranchial, ch: Ceratohyal, et: Ethmoid plate hy: Hyosympletic, m: Meckels, o: Otoliths, p: Parachordal, pa: Palatoquadrate. (B) Unexposed control individuals had normal ethmoid plates, while ethanol-exposed larvae had hypoplastic ethmoid plates with dents in the anterior edge or lack of cells in the midline. The incidence was higher in mutants 45/102 (44%) than in wild types 21/92 (22%). Scale bar (A) 200 μm, (B) 50 μm. Data were analyzed using Chi-square test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.