FIGURE

FIGURE 8

ID

ZDB-FIG-250322-8

Publication

Le et al., 2025 - A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression

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FIGURE 8

Principal component analysis, heatmap, and volcano plot showing DEGs for controls and crim1^−/− larvae. Data from DEGs with adjusted P-values </ = 0.05 and an absolute (log2foldchange) >/ = 1 were used to generate the plots. (A) Three-dimensional PCA plot showing the separation of samples from control larval eyes (blue dots) compared to samples from crim1^−/− larval eyes (red dots). (B) Volcano plot showing differential gene expression for crim1^−/− mutant larvae and controls. The log2 fold change indicates the mean expression level for each gene. Each dot represents one gene. Selected genes with an adjusted P-value </ = 0.01 and absolute (log2foldchange) >/ = 2 have been named. Downregulated genes are shown in blue and upregulated genes are shown in red. (C) Heatmap of expressed genes in crim1^−/− larvae and controls, showing separation of gene expression between control and crim1^−/− mutant larvae. The type of sample (control or crim1^−/− mutant) is listed on the X axis and the Y axis contains DEGs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol