Figure 7.

Event detection at <italic toggle='yes'>Drosophila</italic> neuromuscular synapses upon altered glutamate receptor composition.

(A) Two-electrode voltage-clamp recordings from wild-type (WT) Drosophila NMJs were analyzed using miniML with transfer learning. (B) Left: Example voltage-clamp recording with detected events highlighted. Right: Three individual mEPSCs on expanded time scale. (C) Left: All detected events from the example in (B) overlaid with the average (blue line). Right: Event amplitude histogram. (D–F) Same as in (A–C), but for GluRIIA mutant flies. (G) Comparison of median event amplitude for WT and GluRIIA NMJs. Both groups are plotted on the left axes; Cohen’s d is plotted on a floating axis on the right as a bootstrap sampling distribution (red). The mean difference is depicted as a dot (black); the 95% confidence interval is indicated by the ends of the vertical error bar. (H) Event frequency is lower in GluRIIA mutant NMJs than in WT. (I) Knockout of GluRIIA speeds event decay time. (J) Faster event rise times in GluRIIA mutant NMJs.
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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