FIGURE

Fig. 4

ID

ZDB-FIG-250128-55

Publication

Gimenez et al., 2024 - Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish

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Fig. 4

Granulopoiesis is impaired in rad21+/? WKM but granulocytic maturation is not overtly disrupted. A: UMAP of scRNA-seq data showing the granulocyte cell clusters and Monocle 3 pseudotime trajectory within the granulocytic lineage starting from MPP. B: violin plots showing distribution of pseudotime values for MPP and granulocytic cells. Indicated in blue dots are the median pseudotime values for each cluster. Significance was determined using the Wilcoxon rank-sum test. *P < 0.05, **P < 0.01. C: volcano plot showing DEGs identified in GMP and Gr3 in comparison of rad21+/? versus WT. Red dot signifies statistically significant (adjusted P ? 0.05) DEGs. Shown in green are some of the genes associated with stress. D: violin plots showing the expression of granulocyte marker genes. Significance is from scRNA-seq DESeq2 Wald test. **P < 0.01, ***P < 0.001, ****P < 0.0001. WKM, whole kidney marrow; WT, wild type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Physiol. Cell Physiol.