FIGURE

Fig. 4

ID

ZDB-FIG-250117-27

Publication

Pavic et al., 2024 - Long-chain 4-aminoquinolines inhibit filamentation and increase efficacy of nystatin against Candida albicans infections in vivo

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Fig. 4

Hematotoxicity and liver toxicity of the most potent 4-AQ molecules 6, 11, and 24 compared to HHQ and miconazole.a The hemolytic activity tested on sheep red blood cells was compared with that of HHQ and miconazole, a clinical antifungal drug used as a positive control. b The hemolysis rate was determined in relation to the hemolysis of erythrocytes induced by 1% Triton X, which was arbitrarily set to 100%. Values are average of two independent experiment performed in triplicates ± SD. Statistically significant differences between the treated groups and control (0.1% DMSO) were determined using one-way ANOVA (***P < 0.001). c Hepatotoxicity was evaluated in transgenic Tg(-2,8fabp10:EGFP) zebrafish embryos with fluorescently labeled liver (n = 8) using the liver area index. d The morphology of the transgenic zebrafish embryos and their liver fluorescence after different treatments is shown. One-way ANOVA with the Bonferroni test was used to determine statistical significance by comparing fluorescence signal of the control sample with each treated group (*** P ≤ 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Biofilms Microbiomes