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Fig. 2

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ZDB-FIG-250117-25

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Pavic et al., 2024 - Long-chain 4-aminoquinolines inhibit filamentation and increase efficacy of nystatin against Candida albicans infections in vivo

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Fig. 2

The 4-AQ anti-virulence compounds have a synergistic interaction with nystatin in the suppression of Candida albicans filamentation.Inhibition of filamentation of C. albicans SC5314 in combined treatment with nystatin and 4-AQ molecules (6, 11 and 24) compared to the individual agents, evaluated in RPMI medium (a, b) and Spider medium (c, d). Color-based heat maps (a, c) show the categorized filamentation phenotypes after the 3-day treatments, assessed by the morphology of the fungal colonies (filament density and length, b, d) in comparison to the control (DMSO) as follows: no effect (very dense and long filaments developed; black boxes), weak inhibitory effect (lower filamentation density with long filaments; dark gray boxes), moderate inhibitory effect (short filaments developed; light gray boxes), good inhibitory effect (rare filaments developed; light green boxes), and complete inhibition (no filaments developed; green boxes).

Expression Data

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Antibody Labeling

Phenotype Data

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