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Fig 8

ID

ZDB-FIG-250109-329

Publication

Yu et al., 2024 - The conserved wobble uridine tRNA thiolase Ctu1 is required for angiogenesis and embryonic development

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Fig 8

Model of the consequences of Ctu1 deficiency in zebrafish, figured by Figdraw.

Recently, the essential role of mcm⁵s²U₃₄ tRNA modification and their modifying enzymes in proliferation and development has been demonstrated from yeast to mammals [7]. For example, double deletion of the partner enzymes (Ctu1 and Elp3) is lethal to the cell in yeast [14]. Inactivation of the CTU complex leads to a thermosensitive decrease with aberrant development in the nematode and fission yeast [15]. In mice, a deficiency in Elp1 causes male infertility [52], while Elp3-KO embryos exhibits significant growth retardation and fails to develop beyond E12.5 [13]. Here our finding provides the first experimental evidence that s²U₃₄ tRNA modifying enzyme CTU1 is essential in cellular proliferation and development in vertebrates.

Expression Data

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Antibody Labeling

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Acknowledgments

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