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Fig. 1

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ZDB-FIG-241205-1

Publication

Bowley et al., 2024 - Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation

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Fig. 1

EC proliferation is significantly reduced in embryos without blood flow. Transgenic Tg(fli1a:LifeAct-mClover; fli1a:nls-mCherry) embryos were analysed. The ISVs of four embryos with flow, five tnnt2a-MO (No-Flow), and six tricaine-treated (No-Flow) embryos were imaged from 54 to 70 hpf. For each embryo, data were pooled from 7 ISVs. (A) Representative images showing a dividing EC (arrows) in an ISV exposed to flow. (B) The rate of EC proliferation in the ISVs was quantified as a percentage of nuclei dividing per hour. Mean values + /− standard deviations are shown. Differences between means were analysed using an one-way ANOVA with multiple comparisons.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

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