FIGURE

Fig. 3

ID

ZDB-FIG-241119-130

Publication

Li et al., 2024 - Biallelic loss-of-function variants in GON4L cause microcephaly and brain structure abnormalities

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Fig. 3

Gon4l knockdown in PC12 cells and neurite outgrowth.Knockdown efficiencies of Gon4l mRNA (a) and GON4L protein (b, c) levels in PC12 cells. mRNA levels were normalized against Gusb, and protein levels were normalized against ACTB. Data are shown as the mean � standard error of the mean (SEM) from three independent experiments. d, e Neurite outgrowth assay in Gon4l-knockdown PC12 cells in response to NGF treatment. Representative images (d) and total neurite length in one cell (e) are shown. Dots indicate means of each independent experiment (n = 3), and the bars represent means and SEM of three independent experiments. *p ? 0.05, ***p ? 0.001, ****p ? 0.0001 using one-way analysis of variance (ANOVA) followed by Tukey?s multiple comparison test.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Genom Med