FIGURE

Figure 1

ID

ZDB-FIG-241030-25

Publication

Naderi et al., 2024 - Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions

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Figure 1

Alterations in social behaviors and cognitive performance in kcc2a crispants. Changes in shoaling behavior is shown as (A) mean proximity duration and (B) mean inter-fish distance (n = 4–7). Social preference is shown as (C) the percentage of time spent in the conspecific zone (n = 29–30), and (D) object recognition memory represented by exploration ratio (n = 25–28). The figure also depicts changes in (E,F) shoaling behavior (n = 15–20), (G) social preference (28–30), and (H) object recognition memory (n = 24–28) in fish exposed to VU 0240551 (a KCC2 blocker) and valproic acid (VPA). (I) Representative heat map of zebrafish larvae in social preference and object recognition tasks. The asterisks above data bars represent a significant difference vs. the control group at * p < 0.05, ** p < 0.01, and *** 0.001. “ns” indicates not significant (p > 0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.