FIGURE

Fig. 7

ID

ZDB-FIG-241002-7

Publication

Lavorato et al., 2024 - dldhcri3 zebrafish exhibited altered mitochondrial ultrastructure, morphology and dysfunction partially rescued by probucol or thiamine

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Fig. 7

Intestinal mitochondria in 7 dpf dldh?/? larvae showed depletion of mitochondria with matrix chamber swelling and elongation. (A and B) Mitochondria ultrastructure (light blue) was nicely rounded in WT intestinal cells with well-organized rough reticulum (A), while intestinal cells of 7 dpf dldh?/? zebrafish larvae showed mitochondria (light blue) swelling, damage, and elongation (B). (C?E) Mitochondria ultrastructural morphological features quantified in intestinal cells of WT and dldh?/? larvae mutant larvae. Mitochondria, n = 504 (WT) and 190 (dldh?/?) in 16 cells (WT) and 13 cells (dldh?/?) from 3 WT and 3 dldh?/? larvae. (F?H) Average mitochondrial area, total mitochondrial area, and mitochondria number relative to cross-sectional area . Analysis confirmed increased mitochondrial area and decreased number of mitochondria in dldh?/? larvae relative to WT. All characteristics determined with ImageJ; statistical analyses by Student?s t test, and each point represents data from 1 cell. ****P < 0.0001; **P < 0.01. Data are shown as mean � SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dldh^cri3/cri3 (AB)
Observed In:	intestine mitochondrion
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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