FIGURE

Fig. 3

ID

ZDB-FIG-240930-118

Publication

Shojaeinia et al., 2024 - Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons

Other Figures

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Fig. 3

Partial rescue of dhps knockdown larvae by expression of dhps mRNA at 1 day post-fertilization (1 dpf). (A) Map of pIVT construct with zebrafish dhps cDNA. (B) mRNA overexpression partially shifted the more severe phenotypic categories of dhps knockdown to less severe categories. Chi-square analysis showed significant differences between control, knockdown and rescue groups with regard to the percentages of embryos exhibiting normal development, mild and moderate dysmorphology (P<0.0001). (C) Definition of observed phenotypic categories and sample size of each group

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO3-dhps
Knockdown Reagent:	MO3-dhps
Observed In:	post-vent region whole organism cell death whole organism embryo development
Stage:	Day 5

Phenotype Detail

Acknowledgments

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