FIGURE

Fig. 5

ID

ZDB-FIG-240930-120

Publication

Shojaeinia et al., 2024 - Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons

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Fig. 5

GABAergic neuronal dendritic arborization. (A) Larval head with location of optic tectum (blue) and neuropil (light yellow) where that GABAergic neurons project their arbors. (B) Confocal microscopy revealed that dhps knockdown larvae have less complex dendritic arborization in the GABAergic neurons. (C) GABAergic neuronal arbors were quantified in zebrafish larvae at three different ages (3, 5, and 7 dpf). At all three developmental ages, via one way ANOVA there was a significant reduction in the number of neuronal arbors in the dhps knockdown larvae (dhps E2I2 MO) versus both wild-type control larvae (Wt) and control MO-injected larvae (Crtl MO) (see also Table 1 below)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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