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ZDB-FIG-240829-95

Publication

Han et al., 2024 - Evaluation of the safety and efficacy of cosmetics ingredient Spherulites Paeony Superior Retinol

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Fig. 1

Toxicity of Spherulites Paenoy Superior Retinol and SymRenew™ HPR to zebrafish embryos. (A) The irritation experiment was carried out by exposing 24 hpf zebrafish embryos to 50 μg/mL Spherulites Paenoy Superior Retinol and 5 μg/mL SymRenew™ HPR for 15 min and self-rotation frequencies were recorded, compared with blank control (B). The acute toxicity test was performed by exposing 6 ~ 8 hpf zebrafish embryos to Spherulites Paenoy Superior Retinol and SymRenew™ HPR gradations respectively till 48 hpf. The blank control showed no dead or malformed embryos, the positive control DCA caused 30% mortality and 100% malformation to embryos. (C) Representative photos of embryos at the end of the experiment. (D, E) The mortality and teratogenicity responses and LC50 and TC50 values calculated by regression analysis. Compared with blank control, “**” denotes p < 0.01, “***” denotes p < 0.001.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cosmet. Dermatol.