PUBLICATION

Evaluation of the safety and efficacy of cosmetics ingredient Spherulites Paeony Superior Retinol

Authors
Han, J., Gong, R., Wang, B., Gong, T., Chen, X.
ID
ZDB-PUB-240426-17
Date
2024
Source
Journal of cosmetic dermatology   23(9): 3021-3029 (Journal)
Registered Authors
Chen, Xueping
Keywords
HPR, Spherulites Paenoy Superior Retinol, skin barrier, toxicity, zebrafish embryo
MeSH Terms
  • Animals
  • Skin/drug effects
  • Skin/metabolism
  • Zebrafish*
  • Vitamin A/administration & dosage
  • Vitamin A/pharmacology
  • Embryo, Nonmammalian/drug effects
  • Cosmetics*/administration & dosage
  • Cosmetics*/adverse effects
PubMed
38665039 Full text @ J. Cosmet. Dermatol.
Abstract
Microencapsulation of hydroxypinacolone retinoate (HPR) can improve its application in cosmetics.
To investigate the safety and efficacy of Spherulites Paeony Superior Retinol, a HPR microcapsule containing 5%-10% peony seed oil, 0.01%-1% epigallocatechin gallatyl glucoside (ECGG), and 0.1%-1% HPR.
The safety of Spherulites Paenoy Superior Retinol was evaluated with zebrafish embryo self-rotation irritation test and developmental toxicity test. SymRenew™ HPR was used as a reference. The skin care efficacies of Spherulites Paenoy Superior Retinol were evaluated using zebrafish embryos covering antioxidation, anti-inflammation, blood circulation, whitening, wound healing, skin barrier protection, Type I collagen, elastin, and 5α-reductase genes expression activities.
The irritation test revealed that 250 μg/mL Spherulites Paenoy Superior Retinol did not, while 20 μg/mL SymRenew™ HPR significantly (p < 0.05) increased zebrafish embryo self-rotation frequency. The developmental toxicity test found the teratogenicity index (half lethal concentration/half toxicity concentration) of Spherulites Paenoy Superior Retinol and SymRenew™ HPR were 1.9 and 3.1, respectively. The efficacy analysis results showed that 5 μg/mL Spherulites Paenoy Superior Retinol significantly (p < 0.05) exerted 7.1% anti-ROS, 20% anti-inflammation, 14% enhanced blood circulation, 10% suppressed melanin synthesis, 9% enhanced tail fin regeneration, 72% elicited skin barrier protection activity, enhanced the expression of Type I collagen genes col1a1, col1a2, and col1a2 by 34%, 51%, and 42%, respectively, and elastin gene elna by 46%, and suppressed the expression of 5α-reductase genes srd5a1, srd5a2a, and srd5a2b by 52%, 15%, and 30%, respectively.
This study demonstrated that Spherulites Paenoy Superior Retinol is a safe cosmetic ingredient with multi-skin care efficacies.
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