FIGURE
Fig. 2
- ID
- ZDB-FIG-240802-2
- Publication
- Tanaka et al., 2024 - Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions
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Fig. 2
Identification of the upstream flow-responsive GPCR. (A) Strategy for identification of GPCRs that bind the gain-of-function Gi1Q306K mutant but not the wild-type Gi1. (B) Co-immunoprecipitation of Gi1Q306K(ins4A) with endogenous LPHN2 with and without FSS for 2 min. N = 3, quantified in (C). *P = 0.0374, Student’s t test. (D) Co-immunoprecipitation of LPHN2-GFP with the indicated Gα proteins containing internal GluGlu epitope tags. (E) Gi2 pulldown assay after LPHN2 knockdown. N = 4. Results quantified in (F). ***P < 0.001, Student’s t test. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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