FIGURE

Fig. 7

ID

ZDB-FIG-240730-7

Publication

Roychaudhury et al., 2024 - SRPK3 Is Essential for Cognitive and Ocular Development in Humans and Zebrafish, Explaining X-Linked Intellectual Disability

Other Figures

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Fig. 7

Reduced size of the valvular cerebelli in adult brain of srpk3 KO zebrafish. (A, B) Representative whole brains dissected from a control wild-type (WT) and a knockout (KO) zebrafish. Doral view, anterior is to the left. (C, D‴) Anatomical analysis of brain sections after H&E stain. Frontal sections at 3 different levels indicated in (A). (D″–D‴) Enlargement of valvular cerebelli region in the inlets in (D) and (D′). Asterisk indicates a structural connection between the nucleus lateralis valvulae (NLV) and the valvular cerebelli. Number of adult zebrafish brain used for analysis; n = 3 for WT and n = 3 for KO. CC = corpus cerebelli; DIL = diffuse nucleus of the inferior lobe; NLV = nucleus lateralis valvulae; PGZ = periventricular gray zone of optic tectum; TeO = tectum opticum; TeV = tectal ventricle; TL = torus longitudinalis; Val = lateral division of valvular cerebelli; Vam = medial division of valvular cerebelli.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	srpk3^{ck243a/ck243a} srpk3^{ck243b/ck243b}
Observed In:	valvula cerebelli
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Ann. Neurol.