FIGURE

Fig. 5

ID

ZDB-FIG-240730-5

Publication

Roychaudhury et al., 2024 - SRPK3 Is Essential for Cognitive and Ocular Development in Humans and Zebrafish, Explaining X-Linked Intellectual Disability

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Fig. 5

Analysis of spontaneous eye movements in knockout (KO) zebrafish. (A) Representative image of spontaneous eye movement in wild-type (WT) and KO zebrafish at 5 dpf. (B) Individual representation of spontaneous eye movement in WT and srpk3 KO siblings. Red lines represent right eye and blue lines represent left eye of 5 dpf zebrafish larvae. (C) Eye movement frequency in the left (L) and right (R) eye of srpk3 KO zebrafish when compared to its WT siblings. (D) Ocular angle significantly decreases in both left and right eye in KO zebrafish, compared to WT siblings. (E) srpk3 KO zebrafish take significant longer time to reset in slow phase when compared to their WT siblings during spontaneous eye movement. Video recording of WT (n = 11) and KO (n = 12) zebrafish for 3 min. All data is represented as mean ± SEM. **p < 0.01, ***p < 0.001 by t test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	srpk3^{ck243a/ck243a} srpk3^{ck243b/ck243b}
Observed In:	optokinetic behavior
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Ann. Neurol.