FIGURE

Fig. 2

ID
ZDB-FIG-240703-104
Publication
Liu et al., 2024 - Knockdown of best1 Gene in Zebrafish Caused Abnormal Neuronal and Skeletal Development -A Subtype of Craniovertebral Junction Malformation
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Fig. 2

Nervous system developmental abnormalities caused by best1 knockdown. (A–L) Gross morphology of transgenic (HuC:EGFP) zebrafish embryos at 2-dpf. Compared with control morpholino (MO), knockdown of best1 gene causes head and brain patterning defects (E, I, blue arrowheads), microcephaly (E, I, yellow dotted line), small eyes (E, I, black arrowheads), brain-size reductions (F, J, H, and L), and abnormal neuronal outgrowth (F, J, asterisks). (M–O) Quantification of the head area (M), brain area (N) and average motor axon length (O) shows significantly decrease in best1 morphants. Columns, mean; standard error of the mean (n=10; analysis of variance), ***p < 0.0001. Scale bar, 100 μm. dpf, days post fertilization.

Expression Data
Gene:
Fish:
Knockdown Reagents:
Anatomical Term:
Stage: Long-pec

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagents:
Observed In:
Stage: Long-pec

Phenotype Detail
Acknowledgments
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