FIGURE

Fig. 5

ID

ZDB-FIG-240628-46

Publication

Mashayekhi et al., 2024 - The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages

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Fig. 5

miRNA-Seq data. A, B PCA shows a clear distinction between WT and KO EVs (left) and HCT116 parental and KO cells (right). C, D Differentially expressed miRNAs in EVs (right) and cells (left) are shown as volcano plots. Log2 Fold change is plotted against -log10 p-value (4 biological replicates). E-J The presence of miRNAs was assessed by qPCR in EV and cell samples. The content of miRNAs in EVs (E?G) and cells (H-J) was normalized to 16-5p and U6, respectively, and is shown as fold change relative to WT samples. Statistical analysis was performed using Student's t-test, and data are presented as mean � SD, n = 3, triplicates. # shows a significant difference between WT and KO EVs. K, L KEGG pathway enrichment for miR-181a-5p and miR-452-5p. KEGG pathway enrichment for miR-181a-5p (left) and miR-452-5p (right) are shown. The analysis was performed using miRTargetLink 2.0

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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