FIGURE

Fig. 5

ID

ZDB-FIG-240620-84

Publication

Zhao et al., 2024 - (+)/(-)-Gerbeloid A, a pair of unprecedented coumarin-based polycyclic meroterpenoid enantiomers from Gerbera piloselloides: Structural elucidation, semi-synthesis, and lipid-lowering activity

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Fig. 5

(+)-1a and (?)-1b exert a lipid-lowering effect on HFD zebrafish. (A) Dose-toxicity curve of (+)-1a and (?)-1b on 5 dpf zebrafish. (B) Experimental outline of HFD zebrafish with (+)-1a and (?)-1b treatment. (C) Zebrafish stained with oil red o and visualized under a microscope, Lovastatin, positive control at 2.0 ?g/mL, scale bar, 200, 100 ?m. (D) TG measurement and (E)TC content were determined by manual methods, Lovastatin, positive control at 2.0 ?g/mL. (F) The effects of (+)-1a and (?)-1b on relative mRNA expression level of Pparg. (G) The effects of (+)-1a and (?)-1b on relative mRNA expression level of Cebpa. (H) The effects of (+)-1a and (?)-1b on relative mRNA expression level of Perilipin. The data are expressed as mean � SD (n = 10). ###P < 0.001 vs vehicle, nsP > 0.05, ?P < 0.05, ??P < 0.01, ???P < 0.001 vs Model. L: low concentration; H: high concentration

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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