FIGURE

Fig. 3

ID

ZDB-FIG-240620-75

Publication

Du et al., 2024 - Lapatinib combined with doxorubicin causes dose-dependent cardiotoxicity partially through activating the p38MAPK signaling pathway in zebrafish embryos

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Fig. 3

Oxidative stress was increased in the combined LAP and DOX exposure-induced cardiotoxicity model. (A) Representative fluorescence images of ROS staining in the combined LAP and DOX exposure-induced cardiotoxicity model compared to embryos exposed to LAP or DOX alone or DMSO-treated control embryos. (B-D) Quantification of other ROS-related indices, including catalase (CAT) (B), superoxide dismutase (SOD) (C) and malondialdehyde (MDA) (D), in the LAP and DOX combination-induced cardiotoxicity model compared to embryos exposed to LAP or DOX alone or DMSO-treated control embryos. N=5, one-way ANOVA; (E-J) Quantitative RT-PCR analysis of ROS-related gene expression in the LAP and DOX combination-induced cardiotoxicity model compared to embryos exposed to LAP or DOX alone or DMSO-treated control embryos. N=3 biological repeats. one-way ANOVA. *P<0.05, **P<0.01, ***P<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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