FIGURE

Fig. 7

ID

ZDB-FIG-240620-157

Publication

Marchese et al., 2024 - Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model

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Fig. 7

Consequences of the effective molecules, SG2 and trehalose. (A) Analysis of the effects of the SG2 and trehalose on locomotion (distance traveled and velocity) in cln8−/−. (B) Analysis of the effects of the two compounds on coiling behavior of cln8−/− embryos. The values are expressed as mean ± standard error of the mean (SEM). (C) Analysis of the effects of trehalose and SG2 on the duration and power of LFP events. (D) Analysis of calcium imaging analysis performed by calculating Pearson's coefficient in WT and treated and untreated cln8−/−. The experiments were performed in triplicate. The graphs represent the median and SEM. Statistical analysis (**** p ≤ 0.0001; ***p ≤ 0.001; **p ≤ 0.01; *p ≤ 0.05) was performed using the Mann-Whitney test. Violin plots show the median and quartiles.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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