FIGURE

Fig. 1

ID

ZDB-FIG-240619-16

Publication

Zhang et al., 2024 - TAF1 is needed for the proliferation and maturation of thyroid follicle cells via Notch signaling

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Fig. 1

Identification of taf1 mutations in thyroid mutants. A: the whole morphology of 031003 sibling vs. mutant larvae screened by N-ethyl-N-nitrosourea (ENU). B: thyroid marked by tg in 5 days postfertilization (dpf) embryos using whole mount RNA in situ hybridization (WISH). Nearly 25% of progeny from intercrossed heterozygotes showed an abnormal phenotype. Sibling contained wild-type and heterozygous embryos. C: the tshbα (thyrotrophin) in situ expression pattern in siblings and mutants. D: the 0310003 mutants had lesions in taf1 caused by V241M amino acid substitutions. Verification by Sanger sequencing. E: embryos injected with translation-blocking taf1 morpholinos (taf1-mo) can reproduce the small thyroid phenotype detected at 5 dpf by in situ hybridization. In the control group, embryos were injected with standard control morpholino (sd). Scale bar: 100 μm. tg, thyroglobulin.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Physiol. Endocrinol. Metab.