FIGURE

Fig. 5

ID

ZDB-FIG-240603-35

Publication

Wu et al., 2019 - Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein

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Fig. 5

PS1–BI1 interaction is evolutionarily conserved. (A) Phylogenetic trees of PS1 and BI1. The evolutionary history was inferred using the maximum parsimony method. PS1 and BI1 exhibit a similar pattern of evolutionary history in eukaryotic species, suggesting coevolution of the two proteins. Evolutionary analyses were conducted in MEGA7 (61). (B) PS1 and BI1 homologs interact with each other in four representative model organisms. Shown here are results of the IP-Western assays. (C) BI1 also binds to PS2, which exhibits strong sequence homology to PS1. Shown here are results of the pulldown experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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