FIGURE

Fig. 6

ID

ZDB-FIG-240524-65

Publication

Fiegl et al., 2024 - Laboratory Course Using Zebrafish to Uncover Changing Roles of Wnt Signaling in Early Vertebrate Development

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Fig. 6

Partial reversal of Wnt phenotypes with opposing treatments (student images). LiCl treatment at sphere stage leads to reduction of anterior structures, including the eye (A vs. B). HS induction of hsp:Axin1 expression causes anterior enlargement and posterior trunk defects (A vs. C). With expression of Axin1 after LiCl treatment, eye development is disrupted while trunk defects are milder (D vs. B, C). (26/33 embryos had nearly normal axis formation, 6/33 showed a bent or truncated axis, 1 embryo was severely deformed.) Fli:GFP delineates the ocular region (A′, C′) and its absence (B′, D′), and indicates mild (B′, D′ vs. A′) and severe (C′ vs. A′) perturbation of trunk vessel patterning.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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