FIGURE

Fig. 3

ID

ZDB-FIG-240515-20

Publication

Juliana et al., 2024 - Characterization of the zebrafish as a model of ATP-sensitive potassium channel hyperinsulinism

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Fig. 3

Evaluation of adult zebrafish plasma glucose, insulin, and glucose tolerance. (A) Plasma glucose measurements in adult abcc8+/+ control (95% CI 58, 66) and abcc8-/- (95% CI 63, 75) zebrafish (p=0.059, n=123). (B) Plasma insulin values in adult abcc8+/+ control (95% CI 0.88, 1.49) and abcc8-/- (95% CI 0.91, 1.58) zebrafish (p=0.777, n=13–14 pools). (C) Insulin to glucose ratios in adult abcc8+/+ control (95% CI 0.32, 0.72) and abcc8-/- (95% CI 0.40, 0.97) zebrafish (p=0.3, n=13–14 pools). (D) Glucose tolerance test (GTT) in adult abcc8+/+ control (n=10 zebrafish per time point) and abcc8-/- zebrafish (n=9 zebrafish per timepoint). (E) Area under the curve (AUC) calculations of the GTT in adult zebrafish (p=0.44 comparing abcc8+/+ glucose vs abcc8-/- glucose). Data represent mean±SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	abcc8^{sa15863/sa15863}
Observed In:	blood plasma glucose blood plasma insulin
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMJ Open Diabetes Res Care