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Fig. 3 Evaluation of adult zebrafish plasma glucose, insulin, and glucose tolerance. (A) Plasma glucose measurements in adult abcc8+/+ control (95% CI 58, 66) and abcc8-/- (95% CI 63, 75) zebrafish (p=0.059, n=123). (B) Plasma insulin values in adult abcc8+/+ control (95% CI 0.88, 1.49) and abcc8-/- (95% CI 0.91, 1.58) zebrafish (p=0.777, n=13–14 pools). (C) Insulin to glucose ratios in adult abcc8+/+ control (95% CI 0.32, 0.72) and abcc8-/- (95% CI 0.40, 0.97) zebrafish (p=0.3, n=13–14 pools). (D) Glucose tolerance test (GTT) in adult abcc8+/+ control (n=10 zebrafish per time point) and abcc8-/- zebrafish (n=9 zebrafish per timepoint). (E) Area under the curve (AUC) calculations of the GTT in adult zebrafish (p=0.44 comparing abcc8+/+ glucose vs abcc8-/- glucose). Data represent mean±SEM.