FIGURE

Figure 5

ID

ZDB-FIG-240405-87

Publication

Diana et al., 2024 - Differentiation and functioning of the lateral line organ in zebrafish require Smpx activity

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Figure 5

Smpx-deficiency causes a reduced mechanotransduction activity of the neuromast hair cells. (A–C) Representative images of FM 4–64 incorporation in one control neuromast (ctrlMO) and two Smpx-deficient (smpxMO) neuromasts at 120 hpf (white rectangles on the right of each single image are magnifications of the corresponding, white-dotted rectangles on the left); compared to the control (A), smpx-morphants (B,C) display a reduced FM 4–64 dye uptake. (D) Quantification of the FM 4–64 dye uptake calculated as fluorescence intensity per each neuromast (n = 10 for both controls and morphants). (A–C) Confocal Z-stacks taken from whole mount larvae. (D) Unpaired t-test was performed to assess statistical significance by setting p ≤ 0.05 (*), p ≤ 0.01 (**), p ≤ 0.001 (***) and p ≤ 0.0001 (****) as significant. Scale bars are 50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-smpx
Knockdown Reagent:	MO1-smpx
Observed In:	neuromast hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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