FIGURE

Figure 8

ID

ZDB-FIG-240401-47

Publication

Gil Rosas et al., 2024 - The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP)

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Figure 8

Diagram depicting the working model of TCOF1 transcriptional regulation by G4 and CNBP. Three different conditions showing the possible regulation of TCOF1. (I) Under physiological conditions, several CNBP binding sites in the TCOF1 promoter are occupied by CNBP, Hs2160 is unfolded and transcription proceeds normally. (II) Under high CNBP levels, probably all sites are occupied and extra CNBP may support TCOF1 expression by alternative ways (e.g. mRNA stabilization) either directly or indirectly. (III) Under low CNBP levels, less sites are occupied and Hs2160 has the chance to fold as a G4. Folded Hs2160 can recruit extra factors and induce TCOF1 transcription.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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