FIGURE

Fig. 6

ID

ZDB-FIG-240229-202

Publication

Rizvi et al., 2023 - VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

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Fig. 6

Evidence of BEC-to-hepatocyte conversion in human liver samples from nonalcoholic steatohepatitis (NASH) cirrhosis and alcoholic cirrhosis ESLD patients (A) Immunofluorescence images of p21 expression in 4 out of 5 human cirrhotic liver specimens. (B) Immunofluorescence images of small cuboidal KRT7+ BECs (arrowheads) and KRT7+ intermediate hepatocyte-like cells (arrows) present in the regenerative nodules (asterisks) close to the fibrous septa (outlined). (C) Immunofluorescence images of KRT7+ and GS+ cells in human cirrhotic specimens. White arrowheads depict GS+KRT7+ BECs. White arrows depict the rare GS+KRT7+ intermediate hepatocyte-like cells and yellow arrows the GS+KRT7? intermediate hepatocyte-like cells. See also Figures S6 and S7.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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