FIGURE

Fig. 1.

ID

ZDB-FIG-240229-114

Publication

Mihalič et al., 2024 - Conservation of affinity rather than sequence underlies a dynamic evolution of the motif-mediated p53/MDM2 interaction in ray-finned fishes

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Fig. 1.

Structure of the human MDM2/p53TAD complex. a) Schematic domain architecture of MDM2 and p53. b) Crystal structure of the human complex between the SWIB domain of MDM2 (gold) and a peptide corresponding to the conserved binding motif in p53TAD (blue) (PDBid: 1ycr) (Kussie et al. 1996). Arrows highlight the conserved hydrophobic triad where the residues are shown as sticks. c) Sequence alignment of reconstructed and extant canonical MDM2-binding motifs of p53TAD. To facilitate comparison, the site numbering used here follows the human p53TAD-binding motif, from Ser₁₅ to Pro₂₇. The previously reconstructed maximum likelihood sequence for the most recent common ancestor of bony fishes and tetrapods (Mihalič et al. 2023) is indicated in the alignment as “fish versus tetrapods.”

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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