FIGURE

Fig. 4

ID

ZDB-FIG-240223-34

Publication

Guillemyn et al., 2023 - Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development

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Fig. 4

Five‐dpf‐old uppercut18 zebrafish have compromised chondrocyte morphology and function. Electron micrographs of scrambled zebrafish (A, C, E) show cuboidal (polarized) chondrocytes that are in well‐organized stacks (dashed lines) and contain dense ER membranes that are well developed and organized (arrows), whereas uppercut18 zebrafish (B, D, F) are associated with irregularly formed and organized chondrocytes, distended ER (asterisks), and large amounts of electron‐dense material accumulating in the rough ER (blue arrowheads). n = nucleus. Scale bars (A–F) = 20, 5, and 2 μm, respectively. For A–F, 10 5‐dpf scrambled and crispant zebrafish were analyzed and representative samples are shown.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Bone Miner. Res.